What it is
Vitamin D contributes, under authorised claims, to normal absorption and use of calcium and phosphorus, to the maintenance of normal bones, teeth and muscles, and to normal immune system function. In a supplement the dose must be checked: the EFSA tolerable upper level for adults is 100 µg (4,000 IU) a day.
Also, high spaced doses (ampoules, monthly regimens) are medicines decided by the doctor. At the counter we only discuss the daily supplement dose.
What it does
It helps absorb calcium in the gut and keep it in bone:
- Sunlight makes it in the skin, but in winter and in older people it falls short.
- K2 is added to many products for calcium, with no authorised claim of its own for that pairing.
- The level is measured with a blood test, not guessed.
At the counter
When to recommend it
- Daily dose within the tolerable upper level, with the fattiest meal of the day
- When a blood test or their doctor indicates a shortfall
- The time of day does not change the effect
When not to
- High doses without medical supervision (4,000 IU a day kept up or more)
- Hypercalcaemia or calcium kidney stones without checking first
- Combined with K2 in anyone on acenocoumarol or warfarin, without warning
Warnings
- Important VITAMIN K ANTAGONIST ANTICOAGULANTS (acenocoumarol, warfarin): vitamin K2 can reduce their effect. Do not offer D3+K2 without telling their doctor.
- Important EXCESS: high doses kept up cause hypercalcaemia (nausea, thirst, stones, arrhythmias). More is not better.
- Caution Thiazides and added calcium raise the risk of hypercalcaemia; sarcoidosis and some kidney diseases too.
- Worth knowing Very high dose preparations are medicines with a medical indication.
Pharmacokinetics
- Absorption
- Better with a meal containing fat, because it is fat-soluble.
- Distribution
- Stored in fat and liver.
- Metabolism
- Activated in liver and kidney.
- Elimination
- Slow: it can build up with high doses kept up.
D3 alone and D3 with K2
| Aspect | D3 alone | D3 with K2 |
|---|---|---|
| Claims | Those of vitamin D | Those of each vitamin, none for the pairing |
| Vitamin K antagonist anticoagulants | No problem from the D | K2 can reduce effect |
| Price | Lower | Higher |
| Who needs it | Anyone with a shortfall | No proven advantage |
Added K2 is a risk for some and not a proven advantage for most.
Self-assessment
Three questions. When you check your answers you will see the explanation for each one.
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K2 can reduce the effect of vitamin K antagonists.
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EFSA sets 100 µg a day.
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It is fat-soluble and absorbs better with fat.
Training content. It does not replace the summary of product characteristics or clinical judgement.