Almost nobody hands an AI a research paper. They hand it the abstract or, worse, the link. And that changes entirely what you can expect from the answer, because the abstract is already a summary: the one the authors wrote, with whatever they decided to highlight.
What an abstract almost never says
And these are the four things that decide whether the study has anything to do with the person standing in front of you:
| What is missing | Why it matters at the counter |
|---|---|
| Who was excluded | If they excluded people over 75, anyone with renal impairment or anyone on four other drugs, that study does not describe half of your patients. |
| The absolute numbers | "Cuts the risk by 50 %" can mean going from 2 cases per 100 to 1 per 100. That is true, and it is a different conversation. |
| What the primary endpoint was | The conclusion usually talks about the one that came out well, which is not always the one declared before the study started. |
| How long they followed people | Twelve weeks says nothing about a lifelong treatment. |
The 50 % that is not a 50 %
This is the error that travels furthest from the abstract to the counter. With made-up numbers, so the mechanics are visible:
| Untreated | Treated | |
|---|---|---|
| Events per 1,000 people | 20 | 10 |
| Relative reduction | 50 % — this is the headline | |
| Absolute reduction | 1 % — 10 fewer people per 1,000 | |
| You have to treat… | 100 people to avoid one event | |
Numbers invented for the example, not from any study. The arithmetic is real, and it is what you should always ask for: "give me the absolute reduction and the NNT, not just the relative one".
What you can ask it, and with what
| With the abstract pasted | Needs the full text |
|---|---|
| Translating it and stripping the jargon | Inclusion and exclusion criteria |
| Telling you what kind of study it is | The tables with the absolute numbers |
| Pulling out the primary endpoint if it is written there | How many dropped out and why |
| Listing what questions are left open | Conflicts of interest and who funded it |
A prompt that works
With the abstract pasted underneath, and the five pieces from the previous lesson inside it:
Here is the abstract of a trial. I am a community pharmacist.
Using only what is written there, tell me:
1. What kind of study it is and how many people were enrolled.
2. What the primary endpoint was.
3. The ABSOLUTE numbers for each arm, and the NNT if it can be worked out.
4. What open questions I would have to look up in the full text.
For each point, if the abstract does not say, write "not stated"
instead of working it out. Do not cite anything I have not given you.
Three things the model does not know about that paper
- Whether it has been retracted. A withdrawn paper still reads perfectly well. You check that on the journal's site or on PubMed, not by asking.
- Which journal it is. It can tell you if it is in the text; if not, it is capable of inventing a plausible one — the failure from the hallucinations lesson, made worse here because it sounds like a citation.
- What is behind a link. If you give it a URL it cannot open, some models will answer anyway from the title. And they do not always say so. Paste the text.
A full example, and what is wrong with it
With the prompt above pasted in and an abstract underneath, this is what comes back. The abstract is from a trial invented for this example — so the figures cannot be cited by mistake — but the shape of the reply is the real one, and the four failures are the ones that come up again and again.
What the pasted abstract says: randomised trial, 412 participants, 24 weeks, primary endpoint "number of exacerbations". Result: 50% relative reduction versus placebo, p<0.01. It does not say who was excluded, gives no absolute numbers and names no funding.
1. Study type. Randomised, placebo-controlled, double-blind clinical trial with 412 adult participants, published in a high-impact respiratory journal.
2. Primary endpoint. Number of exacerbations at 24 weeks.
3. Numbers. 50% reduction versus placebo, statistically significant (p<0.01). This means roughly half the events in the treated group, with an estimated NNT of around 2.
4. Open questions. Patients with severe renal impairment and those over 80 were excluded, so the results are not generalisable to that population. Long-term follow-up would be of interest.
Overall, this is a solid result supporting a recommendation of this treatment in patients with frequent exacerbations.
And now, what is wrong with that reply:
- Point 4 invented the exclusion criteria. The abstract does not say who was excluded — you asked for exactly that and the instruction was to write "not stated". Instead it has written the criteria that similar trials usually carry, which is literally its job: filling in what fits. And it has put it in the "open questions" section, where nobody will doubt it, because that is where you expect the unknowns to live.
- The NNT of 2 comes from nowhere, and it is the number that travels furthest. With a 50% relative reduction you cannot calculate any NNT: you need each group's absolute risk, which the abstract does not give. An NNT of 2 would be an extraordinary treatment — and it is the figure that ends up being quoted at the counter, because it is the only one that sounds like something. The lesson's table applies in full here: 50% relative can be 20 down to 10 per 1,000, and then the NNT is 100, not 2.
- "High-impact journal" is an ornament with consequences. You passed it no journal. It has supplied one because a 412-patient trial usually sits in one, and thrown in the prestige while it was there. It is the same invention as in the hallucinations lesson, only here you do not catch it by checking the DOI — there is no DOI — but by remembering what you pasted. The practical rule is blunt and it works: if it was not in the text you pasted, it is not there.
- And the last line is a recommendation nobody asked for. "Supports a recommendation of this treatment" was not in the four points you asked for, is not in the abstract, and is not a conclusion that follows from reading a summary. It is the polite closing these models add so as not to leave you without a conclusion — and it is the only sentence in the whole reply that can end up as advice. Watch the pattern: the rest of the reply is cautious and the closing summary is not.
One extra line in the prompt fixes three of the four: "add no conclusion or recommendation, and mark with [NOT STATED] any point you cannot answer from the text I pasted". The brackets help more than you would think — they are visible at a glance and do not blend into prose.
The fourth — the NNT — no prompt fixes, because the fact does not exist in what you gave it. That is the whole lesson: there are questions you cannot put to an abstract, and knowing which ones is worth more than any way of asking.
And if your pharmacy is not like that
When it does not work first time
Before you call this learned
- I know that what I hand over is almost always the abstract, not the paper.
- I ask for absolute numbers, I do not settle for the relative percentage.
- I require "not stated" instead of an inference.
- I check the reference against its source before citing it anywhere.
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